El siguiente artículo fue realizado por el Centre de Recerco en Sanitat Animal y fue enviado por la responsable de comunicación de la entidad para ser difundido en infopok.com.
Llilianne Gangesa, b, José I. Núñezb, Francisco Sobrinoc, d, Belén Borregod, Natalia Fernández-Borgesb, María T. Frías-Lepoureaue and Fernando Rodríguezb, ,
aDepartamento de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
, INIA, 28040 Madrid, Spain
bCentre de Recerca en Sanitat Animal (CReSA), UAB Bellaterra, 08193 Barcelona, Spain
cCentro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Cantoblanco, 28049 Madrid, Spain
dCentro de Investigación en Sanidad Animal (INIA), Valdeolmos, 28130 Madrid, Spain
eCentro Nacional de Sanidad Agropecuaria (CENSA), La Habana, Cuba
Accepted 25 January 2007. Available online 4 September 2007.
Abstract
Classical swine fever virus (CSFV) is the causative agent of one of the most devastating porcine haemorrhagic viral diseases, classical swine fever (CSF). CSFV mainly infects endothelial cells and macrophages and at the same time promotes bystander apoptosis of the surrounding T cells, causing strong immune suppression and high mortality rates. Most animals experience acute infection, during which they either die or survive by producing neutralising antibodies to the virus. However, in a few cases, the impaired immune system cannot control viral progression, leading to chronic infection. Efficient live attenuated vaccines against CSFV exist and are routinely used only in endemic countries. The ability of these vaccines to replicate in the host, even at very low rates, makes it extremely difficult to distinguish vaccinated from infected animals, favouring a restricted policy regarding vaccination against CSFV in non-endemic countries. There is a clear need for efficient and safer marker vaccines to assist in the control of future CSF outbreaks. In this review article, some of the most recent advances in the field of recombinant vaccines against CSFV are presented and the nature of the protective immune responses they induce is discussed.
Keywords: CSFV; Vaccine; Neutralising antibodies; T cell response; Immune suppression
Further reading
R.J. Moormann, A. Bouma, J.A. Kramps, C. Terpstra and H.J. De Smit, Development of a classical swine fever subunit marker vaccine and companion diagnostic test, Veterinary Microbiology 73 (2000), pp. 209–219.
Contacto con el autor: Tel.: +34 93581 4562; fax: +34 93581 4490.
